Following the events of Resident Evil: Apocalypse, the beautiful, dangerous, enigmatic Alice returns, and this time she and her fellow survivor Carlos Olivera are running with a pack of humans led by a new ally, Claire Redfield. Together they are cutting through the wastelands of the United States on a long trek to Alaska. Hunted by the minions of the scheming Dr. Isaacs, Alice has zombies hungry for her flesh and the Umbrella Corporation's monstrous lab rats hungry for her blood... while Alice herself hungers only for revenge.